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(3,5-Difluorophenyl)hydrazine hydrochloride

  • CAS No. 502496-27-7

  • Cat. No. CS-0042773
  • Purity≥97%
  • MDL No.MFCD03094171

*For research and further manufacturing use only, not for direct human use.

(3,5-Difluorophenyl)hydrazine hydrochloride|CS-0042773

Structure of 502496-27-7

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General Information

  • CAS No. 502496-27-7
  • Cat. No. CS-0042773
  • Purity ≥97%
  • MDL No. MFCD03094171
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClF₂N₂
  • Molecular Weight 180.58
  • Synonym(s) 3,5-Difluorophenylhydrazine hydrochloride
  • SMILES NNC1=CC(F)=CC(F)=C1.[H]Cl

Description

(3,5-Difluorophenyl)hydrazine hydrochloride features a difluorinated aromatic ring that enhances metabolic stability and modulates electronic properties. This bench-stable hydrazine derivative facilitates efficient coupling reactions in the synthesis of heterocycles and functionalized arylazo compounds under mild conditions.

Application

(3,5-Difluorophenyl)hydrazine hydrochloride serves as a reliable building block for the synthesis of heterocyclic scaffolds, particularly in the construction of pyrazoles and triazoles via cycloaddition reactions. Its bench-stable form facilitates handling and purification, while the ortho-difluoro substitution pattern enables further functionalization through palladium-catalyzed coupling processes. The compound functions effectively in standard hydrazone formation and is compatible with diverse reaction conditions in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.6722
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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