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CS-W001157 4
Total: USD 88.00

1-(6-Fluoropyridin-2-yl)ethanone

  • CAS No. 501009-05-8

  • Cat. No. CS-W021247
  • Molecule weight139.13
  • Purity≥98%
  • MDL No.MFCD09263901

*For research and further manufacturing use only, not for direct human use.

1-(6-Fluoropyridin-2-yl)ethanone|CS-W021247

Structure of 501009-05-8

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General Information

  • CAS No. 501009-05-8
  • Cat. No. CS-W021247
  • Purity ≥98%
  • MDL No. MFCD09263901
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) Ethanone,1-(6-fluoro-2-pyridinyl)-
  • SMILES CC(C1=NC(F)=CC=C1)=O

Description

1-(6-Fluoropyridin-2-yl)ethanone features a fluorinated pyridine ring paired with an acetyl group, delivering enhanced electrophilicity at the carbonyl site. This configuration enables efficient coupling in transition-metal-catalyzed cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring electron-deficient heteroaryl motifs. The molecule exhibits good stability under standard bench conditions and is compatible with common organic solvents.

Application

1-(6-Fluoropyridin-2-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based pharmacophores. Its electrophilic acetyl group facilitates nucleophilic substitution and condensation reactions, while the 6-fluoropyridine moiety offers favorable electronic properties for further functionalization. The compound exhibits good bench stability and compatibility with standard synthetic protocols, supporting its use in multi-step synthesis of bioactive molecules.

Synthesis

  • Route1
    • null|null
      676343-47-8
    • null|null
      676-58-4
    • ~90%
    • In-stock
      1-(6-Fluoropyridin-2-yl)ethanone|CS-W021247
      501009-05-8

    References

    • Kuntz, Kevin; Emmitte, Kyle Allen; Rheault, Tara Renae; Smith, Stephon; Hornberger, Keith; Dickson, Hamilton; Cheung, Mui Patent: US2008/300247 A1, 2008 ; Location in patent: Page/Page column 120 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.4233
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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