2-Bromo-3,5-difluoroaniline

Name: 2-Bromo-3,5-difluoroaniline
Brand: ChemScene
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CAS No. 500357-40-4
Cat. No. CS-0099389
Purity≥96%
MDL No.MFCD16661040

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 500357-40-4
Cat. No. CS-0099389
Purity ≥96%
MDL No. MFCD16661040
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrF₂N
Molecular Weight 208.00
Synonym(s) 2-Bromo-3,5-difluorobenzenamine
SMILES NC1=CC(F)=CC(F)=C1Br

Description

2-Bromo-3,5-difluoroaniline features a bromine atom at the ortho position and two fluorine substituents at the meta positions relative to the amino group. This electron-deficient aromatic scaffold integrates readily into pharmaceutical intermediates and agrochemical scaffolds, offering enhanced metabolic stability and controlled reactivity under standard coupling conditions.

Application

2-Bromo-3,5-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of fluorinated aromatic scaffolds. Its orthogonal reactivity profile—combining bromine for Pd-catalyzed cross-coupling and fluoro substituents for electrophilic substitution or nucleophilic displacement—facilitates modular diversification. The compound exhibits excellent bench stability, ease of purification, and compatibility with standard reaction conditions, making it ideal for high-throughput synthetic workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 2.3095
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Bromo-3,5-difluoroaniline

CAS No. 500357-40-4

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