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Benzyl-PEG1-Tos

  • CAS No. 4981-83-3

  • Cat. No. CS-0064453
  • Molecule weight306.38
  • Purity≥98%
  • MDL No.MFCD00027610

*For research and further manufacturing use only, not for direct human use.

Benzyl-PEG1-Tos|CS-0064453

Structure of 4981-83-3

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General Information

  • CAS No. 4981-83-3
  • Cat. No. CS-0064453
  • Purity ≥98%
  • MDL No. MFCD00027610
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₈O₄S
  • Molecular Weight 306.38
  • Synonym(s) None
  • SMILES CC1=CC=C(S(OCCOCC2=CC=CC=C2)(=O)=O)C=C1

Description

Benzyl-PEG1-Tos serves as a reactive linker for conjugation workflows, featuring a tosylate group that facilitates efficient coupling with nucleophiles. The benzyl-protected PEG1 spacer provides enhanced solubility and stability under standard conditions, enabling straightforward integration into peptide or small-molecule synthesis.

Application

Benzyl-PEG1-Tos serves as a versatile bifunctional building block for peptide and small-molecule conjugation. The benzyl group provides a stable, orthogonal handle for selective deprotection, while the PEG1 spacer offers enhanced solubility and reduced aggregation. The tosyl (Tos) group functions as a reliable leaving group in nucleophilic substitution reactions, enabling efficient coupling under mild conditions. This compound facilitates site-specific modifications in synthetic chemistry workflows with excellent bench stability and straightforward purification.

Synthesis

  • Route1

    References

    • Curiel, David; Beer, Paul D.; Tarraga, Alberto; Molina, Pedro Chemistry - A European Journal, 2009 , vol. 15, # 31 p. 7534 - 7538
  • Route2

    References

    • Sankyo Company Limited Patent: US4012429 A1, 1977 ;
  • Route3
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    • Benzyl-PEG1-Tos|CS-0064453
      4981-83-3

    References

    • Ghosh, Suhrit; Ramakrishnan Angewandte Chemie - International Edition, 2005 , vol. 44, # 34 p. 5441 - 5447

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   2.91712
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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