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CS-W001157 4
Total: USD 88.00

Pyrrolidin-2-ylmethanol

  • CAS No. 498-63-5

  • Cat. No. CS-W007622
  • Purity≥95%
  • MDL No.MFCD00601073

*For research and further manufacturing use only, not for direct human use.

Pyrrolidin-2-ylmethanol|CS-W007622

Structure of 498-63-5

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General Information

  • CAS No. 498-63-5
  • Cat. No. CS-W007622
  • Purity ≥95%
  • MDL No. MFCD00601073
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) 2-Pyrrolidinylmethanol
  • SMILES OCC1CCCN1

Description

Pyrrolidin-2-ylmethanol offers a versatile heterocyclic scaffold with a primary alcohol handle, enabling straightforward derivatization. This bench-stable compound integrates readily into synthetic routes for bioactive molecules, serving as a key intermediate in medicinal chemistry and peptide conjugation.

Application

Pyrrolidin-2-ylmethanol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through straightforward functionalization. Its primary amine and hydroxyl groups offer orthogonal reactivity for conjugation, derivatization, or protection, facilitating synthesis of pharmaceutically relevant scaffolds. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1
    • null|null
      41222-21-3
    • ~90%
    • In-stock
      Pyrrolidin-2-ylmethanol|CS-W007622
      498-63-5

    References

    • Pattanayak, Sankha; Sinha, Surajit Tetrahedron Letters, 2011 , vol. 52, # 1 p. 34 - 37
  • Route2

    References

    • Tang, Yi-Qiang; Lu, Jian-Mei; Wang, Xiu-Ren; Shao, Li-Xiong Tetrahedron, 2010 , vol. 66, # 40 p. 7970 - 7974
  • Route3

    References

    • Muller; Stauss Helvetica Chimica Acta, 1982 , vol. 65, # 7 p. 2118 - 2132

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.2693
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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