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2-(Methylsulfonyl)-ethanamine

  • CAS No. 49773-20-8

  • Cat. No. CS-0139140
  • Molecule weight123.17
  • Purity≥96%
  • MDL No.MFCD01862553

*For research and further manufacturing use only, not for direct human use.

2-(Methylsulfonyl)-ethanamine|CS-0139140

Structure of 49773-20-8

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General Information

  • CAS No. 49773-20-8
  • Cat. No. CS-0139140
  • Purity ≥96%
  • MDL No. MFCD01862553
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉NO₂S
  • Molecular Weight 123.17
  • Synonym(s) 2-Aminoethylmethyl sulfone
  • SMILES NCCS(=O)(C)=O

Description

2-(Methylsulfonyl)-ethanamine features a sulfonamide group flanked by a methylene linker and a primary amine, delivering enhanced solubility and metabolic stability. This polar, bench-stable derivative serves as a key scaffold in bioactive molecule design, particularly for targeting protein-ligand interactions in medicinal chemistry applications.

Application

2-(Methylsulfonyl)ethanamine serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable sulfonamide-linked ethylamine moiety. Its amine functionality facilitates straightforward derivatization via alkylation, acylation, or coupling reactions, while the methylsulfonyl group provides enhanced solubility and hydrogen-bonding capacity. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William Patent: WO2012/118812 A2, 2012 ; Location in patent: Page/Page column 324 ; WO 2012/118812 A2
  • Route2
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    • In-stock
      2-(Methylsulfonyl)-ethanamine|CS-0139140
      49773-20-8

    References

    • Knowa Pharmaceutical (Shanghai) Co. Ltd. Patent: EP2305634 A1, 2011 ; Location in patent: Page/Page column 6 ;
  • Route3
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      824938-65-0
    • ~%
    • In-stock
      2-(Methylsulfonyl)-ethanamine|CS-0139140
      49773-20-8

    References

    • Knowa Pharmaceutical (Shanghai) Co. Ltd. Patent: EP2305634 A1, 2011 ; Location in patent: Page/Page column 7 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   -1.0103
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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