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CS-W001157 4
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2-Chloro-7-methoxyquinoline

  • CAS No. 49609-15-6

  • Cat. No. CS-0135015
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-7-methoxyquinoline|CS-0135015

Structure of 49609-15-6

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General Information

  • CAS No. 49609-15-6
  • Cat. No. CS-0135015
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈ClNO
  • Molecular Weight 193.63
  • Synonym(s) Quinoline,2-chloro-7-methoxy
  • SMILES COC1=CC=C2C=CC(Cl)=NC2=C1

Description

2-Chloro-7-methoxyquinoline is a heterocyclic compound featuring a quinoline core with strategic chlorine and methoxy substituents. This combination imparts enhanced electron-withdrawing character and improved solubility in organic solvents, enabling efficient incorporation into synthetic routes for pharmaceutical intermediates and fluorescent probes.

Application

2-Chloro-7-methoxyquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity at the C2 position. The methoxy group at C7 enhances solubility and modulates electronic properties, while the chloro substituent provides high functional group tolerance and bench stability. This compound facilitates efficient access to quinoline-based scaffolds commonly found in kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.8968
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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