(R)-2-Amino-2-cyclopropylacetic acid

Name: (R)-2-Amino-2-cyclopropylacetic acid
Brand: ChemScene
Availability: InStock
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CAS No. 49607-01-4
Cat. No. CS-0054153
Molecule weight115.13
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-Amino-2-cyclopropylacetic acid|CS-0054153

Structure of 49607-01-4

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General Information

CAS No. 49607-01-4
Cat. No. CS-0054153
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₉NO₂
Molecular Weight 115.13
Synonym(s) D-Cyclopropylglycine
SMILES O=C(O)[C@H](N)C1CC1

Description

(R)-2-Amino-2-cyclopropylacetic acid features a chiral cyclopropyl group that imparts distinct stereochemical control in peptide synthesis. This bench-stable derivative integrates readily into bioactive peptidomimetics, offering enhanced metabolic stability and targeted receptor engagement through its rigid, constrained backbone.

Application

(R)-2-Amino-2-cyclopropylacetic acid serves as a stereochemically defined building block for bioactive molecules, featuring a rigid cyclopropyl group that imparts conformational constraint. Its amino and carboxylic acid functionalities enable direct incorporation into peptidomimetics and neurotransmitter analogs via standard amide coupling and derivatization protocols. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis in medicinal chemistry campaigns targeting CNS-active scaffolds.

Synthesis

Route1
- 121703-92-2
- ~0%
- In-stock
  
  49606-99-7
- In-stock
  
  49607-01-4
- 121703-92-2
- 121786-35-4
References
- Chenault, H. Keith; Dahmer, Juergen; Whitesides, George M. Journal of the American Chemical Society, 1989 , vol. 111, # 16 p. 6354 - 6364

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 63.32
LogP -0.1917
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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(R)-2-Amino-2-cyclopropylacetic acid

CAS No. 49607-01-4

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