4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine

Name: 4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 493024-40-1
Cat. No. CS-0205993
Purity≥95%
MDL No.MFCD03424488

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine|CS-0205993

Structure of 493024-40-1

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General Information

CAS No. 493024-40-1
Cat. No. CS-0205993
Purity ≥95%
MDL No. MFCD03424488
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₄FN₃O
Molecular Weight 247.27
Synonym(s) 4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-piperidine
SMILES C1=C(C=CC(=C1)F)C2=NN=C(C3CCNCC3)O2

Description

4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine features a rigid oxadiazole core linked to a fluorinated aryl group and a piperidine heterocycle, delivering enhanced metabolic stability and targeted electronic properties. This combination enables efficient integration into bioactive scaffolds for medicinal chemistry applications, particularly in kinase inhibitor development.

Application

4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds. The 1,3,4-oxadiazole ring imparts metabolic stability and favorable pharmacokinetic properties, while the piperidine moiety offers a basic nitrogen for salt formation and target engagement. This compound exhibits bench stability, facilitates diverse functionalization, and functions effectively in standard coupling and derivatization workflows.

Synthesis

Route1
- 1205637-37-1
- ~%
- In-stock
  
  493024-40-1
References
- WO2013/12723 A1, ; Page/Page column 96 ; WO 2013/012723 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 50.95
LogP 2.3427
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Oxadiazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine

CAS No. 493024-40-1

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