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CS-W001157 4
Total: USD 88.00

2-Bromo-4-methylpyridine

  • CAS No. 4926-28-7

  • Cat. No. CS-W007579
  • Purity≥98%
  • MDL No.MFCD00082590

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-methylpyridine|CS-W007579

Structure of 4926-28-7

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General Information

  • CAS No. 4926-28-7
  • Cat. No. CS-W007579
  • Purity ≥98%
  • MDL No. MFCD00082590
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrN
  • Molecular Weight 172.03
  • Synonym(s) None
  • SMILES C1=C(C=CN=C1Br)C

Application

2-Bromo-4-methylpyridine serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity profile. The bromine atom facilitates efficient functionalization at the C2 position, while the 4-methyl group enhances electronic stability and influences regioselectivity. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy; Knochel, Paul Tetrahedron, 2002 , vol. 58, # 22 p. 4429 - 4438
  • Route2
    • null|null
      108-89-4
    • ~70%
    • In-stock
      2-Bromo-4-methylpyridine|CS-W007579
      4926-28-7

    References

    • Kaminski, Thomas; Gros, Philippe; Fort, Yves European Journal of Organic Chemistry, 2003 , # 19 p. 3855 - 3860
  • Route3
    • null|null
      108-89-4
    • null|null
      78948-09-1
    • ~53%
    • In-stock
      2-Bromo-4-methylpyridine|CS-W007579
      4926-28-7
    • null|null
      108168-80-5

    References

    • Hebel, David; Rozen, Shlomo Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6298 - 6301

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.15252
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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