tert-Butyl 4-pyridazin-3-ylpiperazine-1-carboxylate

Name: tert-Butyl 4-pyridazin-3-ylpiperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 492431-12-6
Cat. No. CS-0072136
Molecule weight264.32
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
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tert-Butyl 4-pyridazin-3-ylpiperazine-1-carboxylate|CS-0072136

Structure of 492431-12-6

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General Information

CAS No. 492431-12-6
Cat. No. CS-0072136
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₀N₄O₂
Molecular Weight 264.32
Synonym(s) 1-Piperazinecarboxylic acid, 4-(3-pyridazinyl)-, 1,1-dimethylethyl ester
SMILES O=C(N1CCN(C2=NN=CC=C2)CC1)OC(C)(C)C

Description

tert-Butyl 4-pyridazin-3-ylpiperazine-1-carboxylate is a bench-stable, moisture-tolerant building block featuring a pyridazinyl-piperazine scaffold. This compound integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators, offering high solubility in organic solvents and compatibility with standard deprotection protocols.

Application

tert-Butyl 4-pyridazin-3-ylpiperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridazinylpiperazine scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. Its piperazine core exhibits broad functional group tolerance and participates reliably in standard coupling reactions, making it ideal for modular synthesis of bioactive molecules.

Synthesis

Route1
- In-stock
  
  492431-11-5
- ~%
- In-stock
  
  492431-12-6
References
- sanofi-aventis Patent: US2005/176722 A1, 2005 ; Location in patent: Page/Page column 19 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

TPSA 58.56
LogP 1.5337
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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tert-Butyl 4-pyridazin-3-ylpiperazine-1-carboxylate

CAS No. 492431-12-6

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