Lot numbers can be found on the outside label of a product:
1-Methyl-1,2,3,4-tetrahydroquinoline
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CAS No. 491-34-9
- Cat. No. CS-0151091
- Purity≥97%
- MDL No.MFCD00130001
*For research and further manufacturing use only, not for direct human use.
Structure of 491-34-9
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General Information
- CAS No. 491-34-9
- Cat. No. CS-0151091
- Purity ≥97%
- MDL No. MFCD00130001
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₃N
- Molecular Weight 147.22
- Synonym(s) 1,2,3,4-tetrahydro-1-methylquinoline
- SMILES CN1CCCC2=CC=CC=C21
Description
1-Methyl-1,2,3,4-tetrahydroquinoline features a saturated quinoline core with a methyl group at the nitrogen, enhancing electron density and improving solubility in organic solvents. This bench-stable heterocycle serves as a key scaffold in medicinal chemistry for targeting CNS receptors and designing bioactive molecules.
Application
1-Methyl-1,2,3,4-tetrahydroquinoline serves as a versatile heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and improved solubility compared to parent quinoline systems. Its tertiary amine functionality enables salt formation and facilitates downstream functionalization via electrophilic substitution or transition-metal-catalyzed coupling. Bench-stable and readily purified by chromatography, it functions as a key building block for kinase inhibitors, CNS-targeted agents, and other bioactive molecules.
Synthesis
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Route1
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In-stock
635-46-1 -
74-88-4 - ~70%
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In-stock
491-34-9
References
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Ahlbrecht,H.; Duebner,E.O. Tetrahedron, 1984 , vol. 40, p. 1157
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Route2
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In-stock
635-46-1
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77-78-1
- ~62%
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In-stock
491-34-9
References
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THE WELLCOME FOUNDATION LIMITED Patent: EP96214 B1, 1991 ;
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Route3
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In-stock
635-46-1
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50-00-0
- ~93%
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In-stock
491-34-9
References
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Yeon Joo Jung; Jong Woo Bae; Choon-Ock Maing Yoon; Byung Woo Yoo; Cheol Min Yoon Synthetic Communications, 2001 , vol. 31, # 22 p. 3417 - 3421
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 3.24
- LogP 2.069
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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