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CS-W001157 4
Total: USD 88.00

5-Bromo-1H-benzo[d]imidazole

  • CAS No. 4887-88-1

  • Cat. No. CS-W007490
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1H-benzo[d]imidazole|CS-W007490

Structure of 4887-88-1

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General Information

  • CAS No. 4887-88-1
  • Cat. No. CS-W007490
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂
  • Molecular Weight 197.03
  • Synonym(s) 6-bromo-1H-benzimidazole
  • SMILES BrC1=CC=C2C(N=CN2)=C1

Description

A glycoside used to permeabilize cellular membranesSaponin is used as dietary supplements and nutraceuticals and as adjuvants in the production of vaccines. It finds application in food, cosmetics and pharmaceutical sectors. It is used as a liquid soap, jewelry polish, detergent, pet shampoo, surfactant and wetting agent. It is also involved as anti-microbe to treat malaria, lower cholesterol, support to immune system, in bone strength and for hyper tension. Further, it is used as animal feed and an automobile cleaner.

Application

5-Bromo-1H-benzo[d]imidazole serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent. The benzimidazole core provides excellent functional group tolerance and bench stability, facilitating straightforward incorporation into complex heterocyclic architectures and API scaffolds.

Synthesis

  • Route1
    • In-stock
      4-Bromo-1,2-benzenediamine|CS-W008701
      1575-37-7
    • null|null
      149-73-5
    • ~98%
    • In-stock
      5-Bromo-1H-benzo[d]imidazole|CS-W007490
      4887-88-1

    References

    • Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng Patent: US2013/102595 A1, 2013 ; Location in patent: Paragraph 0580; 0581 ;
  • Route2

    References

    • Pu, Shuai; Liang, Qiuxiang; Luo, Xi; Luo, Juan Journal of Chemical Research, 2014 , vol. 38, # 2 p. 118 - 120
  • Route3
    • null|null
      64-18-6
    • In-stock
      4-Bromo-1,2-benzenediamine|CS-W008701
      1575-37-7
    • ~99%
    • In-stock
      5-Bromo-1H-benzo[d]imidazole|CS-W007490
      4887-88-1

    References

    • F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim Patent: WO2013/26914 A1, 2013 ; Location in patent: Page/Page column 131 ; WO 2013/026914 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.3254
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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