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CS-W001157 4
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2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride

  • CAS No. 4876-14-6

  • Cat. No. CS-W021544
  • Purity≥96%
  • MDL No.MFCD07787426

*For research and further manufacturing use only, not for direct human use.

2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride|CS-W021544

Structure of 4876-14-6

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General Information

  • CAS No. 4876-14-6
  • Cat. No. CS-W021544
  • Purity ≥96%
  • MDL No. MFCD07787426
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃ClN₂O₃
  • Molecular Weight 268.70
  • Synonym(s) None
  • SMILES Cl[H].NC(CC1=CC(=O)NC2=CC=CC=C12)C(O)=O

Description

This hydrochloride salt features a quinolinone core functionalized with a β-amino acid side chain, enabling direct integration into peptide-based scaffolds. The protonated amine enhances solubility and stability under standard conditions, while the electron-deficient quinoline ring facilitates selective conjugation in synthetic biology applications.

Application

2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride serves as a versatile building block for constructing quinoline-based heterocyclic scaffolds and bioactive molecules. Its amine and carboxylic acid functionalities enable straightforward derivatization via coupling reactions, while the dihydroquinolinone core provides structural rigidity and enhanced metabolic stability. The hydrochloride salt improves bench stability and solubility, facilitating purification and handling in synthetic workflows.

Synthesis

  • Route1

    References

    • Uchida; Tabusa; Komatsu; Morita; Kanbe; Nakagawa Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3775 - 3786
  • Route2

    References

    • Uchida; Tabusa; Komatsu; Morita; Kanbe; Nakagawa Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3775 - 3786

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   96.18
  • LogP   0.9043
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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