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CS-W001157 4
Total: USD 88.00

1,6-Bismaleimidohexane

  • CAS No. 4856-87-5

  • Cat. No. CS-W017777
  • Purity≥95%
  • MDL No.MFCD00047122

*For research and further manufacturing use only, not for direct human use.

1,6-Bismaleimidohexane|CS-W017777

Structure of 4856-87-5

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General Information

  • CAS No. 4856-87-5
  • Cat. No. CS-W017777
  • Purity ≥95%
  • MDL No. MFCD00047122
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₆N₂O₄
  • Molecular Weight 276.29
  • Synonym(s) None
  • SMILES O=C(N1CCCCCCN2C(C=CC2=O)=O)C=CC1=O

Description

Azido-PEG8-hydrazide HCl salt is a wter soluble PEG linker containing an azide group and a hydrazide moiety. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond.

Synthesis

  • Route1
    • null|null
      108-31-6
    • null|null
      124-09-4
    • ~48%
    • In-stock
      1,6-Bismaleimidohexane|CS-W017777
      4856-87-5

    References

    • Asadirad, Amir Mahmoud; Boutault, Stephanie; Erno, Zach; Branda, Neil R. Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3024 - 3027
  • Route2
    • null|null
      124-09-4
    • In-stock
      Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate|CS-W008141
      55750-48-6
    • ~61%
    • In-stock
      1,6-Bismaleimidohexane|CS-W017777
      4856-87-5

    References

    • Cheronis, John C.; Whalley, Eric T.; Nguyen, Khe T.; Eubanks, Shad R.; Allen, Lisa G.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1563 - 1572
  • Route3

    References

    • Patel, Dinesh G.; Graham, Kenneth R.; Reynolds, John R. Journal of Materials Chemistry, 2012 , vol. 22, # 7 p. 3004 - 3014

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H311-H315-H319
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   74.76
  • LogP   0.3968
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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