tert-Butyl 4-(chloromethyl)piperidine-1-carboxylate

Name: tert-Butyl 4-(chloromethyl)piperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 479057-79-9
Cat. No. CS-0112988
Molecule weight233.74
Purity≥96%
MDL No.MFCD08689676

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(chloromethyl)piperidine-1-carboxylate|CS-0112988

Structure of 479057-79-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 479057-79-9
Cat. No. CS-0112988
Purity ≥96%
MDL No. MFCD08689676
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₀ClNO₂
Molecular Weight 233.74
Synonym(s) tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate
SMILES O=C(N1CCC(CCl)CC1)OC(C)(C)C

Description

tert-Butyl 4-(chloromethyl)piperidine-1-carboxylate features a reactive chloromethyl group appended to a piperidine scaffold, enabling efficient conjugation in late-stage functionalization. This bench-stable reagent integrates readily into synthetic workflows requiring selective alkylation, particularly in medicinal chemistry and fragment-based drug discovery.

Application

tert-Butyl 4-(chloromethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient introduction of piperidine scaffolds with a reactive chloromethyl handle. The tert-butyl ester provides excellent bench stability and facilitates mild deprotection under acidic conditions. The chloromethyl group participates reliably in nucleophilic substitutions, including azide displacement and amine coupling, supporting rapid diversification in lead optimization campaigns.

Synthesis

Route1
- In-stock
  
  123855-51-6
- ~98%
- In-stock
  
  479057-79-9
References
- WO2006/20415 A1, ; Page/Page column 61; 62 ; WO 2006/020415 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 29.54
LogP 2.8723
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

479057-79-9 sigma479057-79-9 manufacturer479057-79-9 price479057-79-9 structure479057-79-9 SDSbuy 479057-79-9479057-79-9 supplier479057-79-9 uses479057-79-9 molecular weightprice of 479057-79-9479057-79-9 chemical name formula of 479057-79-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl 4-(chloromethyl)piperidine-1-carboxylate

CAS No. 479057-79-9

Recommended Products