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CS-W001157 4
Total: USD 88.00

2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline

  • CAS No. 479-59-4

  • Cat. No. CS-0128844
  • Purity≥97%
  • MDL No.MFCD00006917

*For research and further manufacturing use only, not for direct human use.

2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline|CS-0128844

Structure of 479-59-4

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General Information

  • CAS No. 479-59-4
  • Cat. No. CS-0128844
  • Purity ≥97%
  • MDL No. MFCD00006917
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅N
  • Molecular Weight 173.25
  • Synonym(s) Julolidine
  • SMILES C12=CC=CC3=C1N(CCC3)CCC2

Description

This tetrahydroquinoline scaffold delivers a rigid, electron-rich heterocyclic core ideal for medicinal chemistry applications. Featuring a well-defined fusion of pyridine and quinoline systems, it enables precise spatial positioning in bioactive molecules. The saturated ring system enhances metabolic stability while maintaining favorable solubility profiles.

Application

2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline serves as a versatile heterocyclic scaffold in medicinal chemistry, offering a rigid, planar core with defined nitrogen positioning. It functions as a key building block for bioactive molecules, enabling efficient access to fused polycyclic systems via standard functionalization and coupling reactions. The compound exhibits good bench stability and facilitates downstream derivatization due to its well-defined reactivity profile and compatibility with common protecting group strategies.

Synthesis

  • Route1

    References

    • Pan, Yijun; Holmes, Christopher P. Organic Letters, 2001 , vol. 3, # 17 p. 2769 - 2770
  • Route2
    • null|null
      5279-24-3
    • ~%
    • In-stock
      2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline|CS-0128844
      479-59-4

    References

    • Rindfusz; Harnack Journal of the American Chemical Society, 1920 , vol. 42, p. 1723
  • Route3
    • null|null
      74497-02-2
    • ~%
    • In-stock
      2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline|CS-0128844
      479-59-4

    References

    • Rindfusz; Harnack Journal of the American Chemical Society, 1920 , vol. 42, p. 1723

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   2.3854
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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