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CS-W001157 4
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3-Methoxy-6-methylpyridin-2-amine

  • CAS No. 478913-57-4

  • Cat. No. CS-0145993
  • Purity≥96%
  • MDL No.MFCD09878490

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-6-methylpyridin-2-amine|CS-0145993

Structure of 478913-57-4

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General Information

  • CAS No. 478913-57-4
  • Cat. No. CS-0145993
  • Purity ≥96%
  • MDL No. MFCD09878490
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 3-Methoxy-6-methyl-pyridin-2-ylamine
  • SMILES NC1=NC(C)=CC=C1OC

Description

3-Methoxy-6-methylpyridin-2-amine features a pyridine core functionalized with methoxy and methyl groups at the 3- and 6-positions, respectively, and a primary amine at the 2-position. This arrangement imparts enhanced solubility and electronic modulation, enabling its use in targeted synthesis of bioactive heterocycles and pharmaceutical intermediates.

Application

3-Methoxy-6-methylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds through standard coupling and functionalization reactions. Its ortho-directed reactivity and bench-stable nature facilitate straightforward incorporation into diverse heterocyclic architectures. The methoxy and methyl groups provide favorable electronic and steric profiles for downstream derivatization, making it well-suited for parallel synthesis campaigns and API development workflows.

Synthesis

  • Route1
    • 3-Methoxy-6-methyl-2-nitropyridine|CS-0450038
      24015-98-3
    • ~%
    • In-stock
      3-Methoxy-6-methylpyridin-2-amine|CS-0145993
      478913-57-4

    References

    • Takeda Chemical Industries, Ltd. Patent: EP1591446 A1, 2005 ; Location in patent: Page/Page column 27 ;
  • Route2
    • null|null
      74-88-4
    • In-stock
      6-Methyl-2-nitropyridin-3-ol|CS-W018055
      15128-90-2
    • ~%
    • In-stock
      3-Methoxy-6-methylpyridin-2-amine|CS-0145993
      478913-57-4

    References

    • Kyorin Pharmaceutical Co., Ltd. Patent: EP2168960 A1, 2010 ; Location in patent: Page/Page column 70 ;
  • Route3

    References

    • Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tetsuya; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David R.; Allcock, Robert W.; Jiang, Zhong; Kohno, Yasushi Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1644 - 1658

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.98082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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