exo-3-Fluoro-8-azabicyclo[3.2.1]octane hydrochloride

Name: exo-3-Fluoro-8-azabicyclo[3.2.1]octane hydrochloride
Brand: ChemScene
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CAS No. 478866-38-5
Cat. No. CS-0049366
Purity≥97%
MDL No.MFCD28506182

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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exo-3-Fluoro-8-azabicyclo[3.2.1]octane hydrochloride|CS-0049366

Structure of 478866-38-5

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General Information

CAS No. 478866-38-5
Cat. No. CS-0049366
Purity ≥97%
MDL No. MFCD28506182
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₃ClFN
Molecular Weight 165.64
Synonym(s) EXO-3-FLUORO-8-AZABICYCLO[3.2.1]OCTANE HCL
SMILES F[C@H]1C[C@@H]2CC[C@@H](N2)C1.Cl

Description

exo-3-Fluoro-8-azabicyclo[3.2.1]octane hydrochloride is a sterically defined, bench-stable heterocyclic scaffold featuring a fluorinated exo-position and a protonated nitrogen within a rigid bicyclic framework. This configuration imparts enhanced metabolic stability and favorable pharmacokinetic properties, enabling its integration into bioactive molecules for medicinal chemistry applications.

Application

exo-3-Fluoro-8-azabicyclo[3.2.1]octane hydrochloride serves as a conformationally constrained, fluorinated nitrogen heterocycle ideal for medicinal chemistry applications. The exo-fluorine enhances metabolic stability and modulates electronic properties, while the bicyclic scaffold provides rigidity to probe target binding pockets. Its hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling in standard coupling and functionalization reactions. Functions as a key building block for CNS-targeted compounds and kinase inhibitors.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP 1.6607
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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exo-3-Fluoro-8-azabicyclo[3.2.1]octane hydrochloride

CAS No. 478866-38-5

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