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CS-W001157 4
Total: USD 88.00

2-Phenoxypyridine

  • CAS No. 4783-68-0

  • Cat. No. CS-0060561
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Phenoxypyridine|CS-0060561

Structure of 4783-68-0

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General Information

  • CAS No. 4783-68-0
  • Cat. No. CS-0060561
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO
  • Molecular Weight 171.20
  • Synonym(s) Picosulfate Impurity 14
  • SMILES C1=CC=C(C=C1)OC2=CC=CC=N2

Description

2-Phenoxypyridine features a pyridine ring fused to a phenyl ether moiety, delivering enhanced electronic modulation and improved solubility in organic media. This structural arrangement enables efficient coordination in transition metal catalysis and facilitates incorporation into functional ligands for asymmetric synthesis.

Application

2-Phenoxypyridine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling reactions. Its ortho-substituted pyridine core provides enhanced stability and favorable electronic properties for C–H functionalization. The phenoxypyridine scaffold exhibits good bench stability, mild purification requirements, and tolerance to diverse functional groups, facilitating its use in multi-step syntheses of pharmaceutical intermediates and agrochemicals.

Synthesis

  • Route1
    • null|null
      109-04-6
    • null|null
      108-95-2
    • ~99%
    • In-stock
      2-Phenoxypyridine|CS-0060561
      4783-68-0

    References

    • Kuska, Michael S.; Majdi Yazdi, Mohadeseh; Witham, Aaron A.; Dahlmann, Heidi A.; Sturla, Shana J.; Wetmore, Stacey D.; Manderville, Richard A. Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7176 - 7185
  • Route2
    • null|null
      109-09-1
    • null|null
      108-95-2
    • ~98%
    • In-stock
      2-Phenoxypyridine|CS-0060561
      4783-68-0

    References

    • Platon, Melanie; Cui, Luchao; Mom, Sophal; Richard, Philippe; Saeys, Mark; Hierso, Jean-Cyrille Advanced Synthesis and Catalysis, 2011 , vol. 353, # 18 p. 3403 - 3414
  • Route3
    • α-Pyridone Levetiracetam Impurity|CS-0213990
      142-08-5
    • In-stock
      Iodobenzene|CS-W008603
      591-50-4
    • ~1%
    • 1-Phenylpyridin-2(1H)-one|CS-0047711
      13131-02-7
    • In-stock
      2-Phenoxypyridine|CS-0060561
      4783-68-0

    References

    • Cristau, Henri-Jean; Cellier, Pascal P.; Spindler, Jean-Francis; Taillefer, Marc Chemistry - A European Journal, 2004 , vol. 10, # 22 p. 5607 - 5622

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.8739
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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