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CS-W001157 4
Total: USD 88.00

6-Methoxy-5-nitropicolinic acid

  • CAS No. 475272-62-9

  • Cat. No. CS-0040710
  • Purity≥97%
  • MDL No.MFCD18261308

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-5-nitropicolinic acid|CS-0040710

Structure of 475272-62-9

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General Information

  • CAS No. 475272-62-9
  • Cat. No. CS-0040710
  • Purity ≥97%
  • MDL No. MFCD18261308
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂O₅
  • Molecular Weight 198.13
  • Synonym(s) 6-Methoxy-5-nitro-pyridine-2-carboxylic acid
  • SMILES O=C(C1=NC(OC)=C([N+]([O-])=O)C=C1)O

Description

6-Methoxy-5-nitropicolinic acid features a pyridine core functionalized with a nitro group at C5 and a methoxy substituent at C6, delivering enhanced electron-withdrawing character and improved solubility. This combination enables efficient coordination in metal-ligand systems and facilitates downstream derivatization in synthetic applications requiring polar, bench-stable intermediates.

Application

6-Methoxy-5-nitropicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through its orthogonal functionalization potential. The nitro group facilitates reduction and subsequent coupling reactions, while the methoxy substituent enhances solubility and modulates electronic properties. This compound exhibits bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows and API scaffold development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   102.56
  • LogP   0.6966
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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