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CS-W001157 4
Total: USD 88.00

(9H-Fluoren-9-yl)methyl (4-(hydroxymethyl)phenyl)carbamate

  • CAS No. 475160-83-9

  • Cat. No. CS-0120224
  • Purity≥95%
  • MDL No.MFCD04974272

*For research and further manufacturing use only, not for direct human use.

(9H-Fluoren-9-yl)methyl (4-(hydroxymethyl)phenyl)carbamate|CS-0120224

Structure of 475160-83-9

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General Information

  • CAS No. 475160-83-9
  • Cat. No. CS-0120224
  • Purity ≥95%
  • MDL No. MFCD04974272
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₁₉NO₃
  • Molecular Weight None
  • Synonym(s) FMOC-4-AMINOBENZYLALCOHOL
  • SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NC4=CC=C(CO)C=C4

Description

This fluoren-9-ylmethyl carbamate derivative features a pendant hydroxymethylphenyl group, enabling straightforward conjugation and protection strategies in peptide synthesis. The fluorenyl moiety provides excellent solubility and stability under standard conditions, while the carbamate linkage offers reliable deprotection via mild acidolysis.

Application

(9H-Fluoren-9-yl)methyl (4-(hydroxymethyl)phenyl)carbamate serves as a robust, bench-stable amino protecting group for peptide synthesis and amine-functionalized intermediates. Its fluorenylmethoxycarbonyl (Fmoc) moiety enables selective deprotection under mild basic conditions, while the pendant hydroxymethylphenyl group offers orthogonal functionality for further derivatization. The compound exhibits excellent solubility in common organic solvents, facilitates efficient coupling reactions, and simplifies purification by crystallization or chromatography—making it well-suited for scalable synthetic workflows in medicinal chemistry and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   4.5399
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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