6-Bromo-8-fluoroimidazo[1,2-a]pyridine

Name: 6-Bromo-8-fluoroimidazo[1,2-a]pyridine
Brand: ChemScene
Availability: InStock
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CAS No. 474709-06-3
Cat. No. CS-0037702
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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6-Bromo-8-fluoroimidazo[1,2-a]pyridine|CS-0037702

Structure of 474709-06-3

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General Information

CAS No. 474709-06-3
Cat. No. CS-0037702
Purity ≥96%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrFN₂
Molecular Weight 215.02
Synonym(s) None
SMILES C1=CN2C=C(C=C(C2=N1)F)Br

Description

6-Bromo-8-fluoroimidazo[1,2-a]pyridine is a heterocyclic scaffold featuring bromo and fluoro substituents at electron-deficient positions, enabling direct functionalization in cross-coupling reactions. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures for medicinal chemistry and materials science applications.

Application

6-Bromo-8-fluoroimidazo[1,2-a]pyridine serves as a versatile building block for constructing bioactive heterocycles in medicinal chemistry. Its orthogonal halogenation pattern enables palladium-catalyzed cross-coupling reactions with high efficiency and selectivity. The molecule exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in standard coupling protocols, making it well-suited for the modular synthesis of complex imidazopyridine scaffolds.

Synthesis

Route1
- 474709-05-2
- ~%
- In-stock
  
  474709-06-3
References
- Eisai Co., Ltd. Patent: EP1382603 A1, 2004 ; Location in patent: Page 134 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 17.3
LogP 2.2359
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-8-fluoroimidazo[1,2-a]pyridine

CAS No. 474709-06-3

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