Monomethyl auristatin E

Name: Monomethyl auristatin E
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CAS No. 474645-27-7
Cat. No. CS-0837
Purity≥97%
MDL No.MFCD22124498

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 474645-27-7
Cat. No. CS-0837
Purity ≥97%
MDL No. MFCD22124498
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₉H₆₇N₅O₇
Molecular Weight 717.98
Synonym(s) MMAE; SGD-1010
SMILES CC(C)[C@H](NC)C(N[C@@H](C(C)C)C(N(C)[C@H]([C@@H](CC(N1[C@]([C@H](OC)[C@H](C(N[C@@H]([C@H](C2=CC=CC=C2)O)C)=O)C)(CCC1)[H])=O)OC)[C@H](CC)C)=O)=O

Description

Monomethyl auristatin E delivers potent cytotoxic activity through irreversible microtubule disruption, enabling precise targeting in antibody-drug conjugates. This synthetic peptide moiety features a stable, hydrophobic structure with enhanced cell permeability and resistance to metabolic degradation, ensuring sustained intracellular efficacy.

Application

Monomethyl auristatin E serves as a potent cytotoxic payload in antibody-drug conjugates, leveraging its mechanism of microtubule disruption to induce cell cycle arrest. Its stable maleimide-functionalized derivative enables site-specific conjugation to monoclonal antibodies via thiol-reactive coupling. The compound exhibits high potency and favorable pharmacokinetic properties in preclinical models, making it a key building block for targeted cancer therapeutics.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 149.54
LogP 3.5298
H_Acceptors 8
H_Donors 4
Rotatable_Bonds 20

Other Classifications

Life Science ADC Related Compound Payload

Building Blocks Functional Group Amine

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Amide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

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Monomethyl auristatin E

CAS No. 474645-27-7

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