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CS-W001157 4
Total: USD 88.00

3,5-Dibromo-2-fluoropyridine

  • CAS No. 473596-07-5

  • Cat. No. CS-W014086
  • Purity≥98%
  • MDL No.MFCD07368619

*For research and further manufacturing use only, not for direct human use.

3,5-Dibromo-2-fluoropyridine|CS-W014086

Structure of 473596-07-5

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General Information

  • CAS No. 473596-07-5
  • Cat. No. CS-W014086
  • Purity ≥98%
  • MDL No. MFCD07368619
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Br₂FN
  • Molecular Weight None
  • Synonym(s) Pyridine, 3,5-dibromo-2-fluoro-
  • SMILES BrC1=CC(=CN=C1F)Br

Description

3,5-Dibromo-2-fluoropyridine features a fluorinated pyridine core with bromine substituents at the 3 and 5 positions, enabling selective cross-coupling reactions. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity under palladium catalysis. The combination of fluorine and bromine groups provides orthogonal handling for sequential transformations.

Application

3,5-Dibromo-2-fluoropyridine serves as a versatile building block for the synthesis of substituted pyridines and heterocyclic scaffolds in medicinal chemistry. The ortho-fluoro substituent enables palladium-catalyzed cross-coupling reactions, while the dibromo groups provide complementary sites for further functionalization via Suzuki-Miyaura or Negishi couplings. Its bench-stable nature and predictable reactivity make it well-suited for iterative synthetic sequences in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7457
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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