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2-Amino-3-thiophenecarbonitrile

  • CAS No. 4651-82-5

  • Cat. No. CS-0021992
  • Purity≥96%
  • MDL No.MFCD00706298

*For research and further manufacturing use only, not for direct human use.

2-Amino-3-thiophenecarbonitrile|CS-0021992

Structure of 4651-82-5

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General Information

  • CAS No. 4651-82-5
  • Cat. No. CS-0021992
  • Purity ≥96%
  • MDL No. MFCD00706298
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂S
  • Molecular Weight 124.16
  • Synonym(s) 2-Aminothiophene-3-carbonitrile
  • SMILES N#CC1=C(N)SC=C1

Description

2-Amino-3-thiophenecarbonitrile features a thiophene core functionalized with an amino group at position 2 and a nitrile at position 3, delivering high electron density and enhanced reactivity. This scaffold enables efficient integration into heterocyclic architectures and serves as a key building block for pharmaceutical intermediates and advanced materials.

Application

2-Amino-3-thiophenecarbonitrile serves as a versatile building block for heterocyclic synthesis, enabling efficient access to thiophene-based scaffolds prevalent in medicinal chemistry. Its dual functionality—amino and nitrile groups—facilitates diverse transformations including cyclizations, nucleophilic additions, and metal-catalyzed couplings. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for use in iterative synthetic campaigns targeting bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.81
  • LogP   1.20198
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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