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CS-W001157 4
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1-Bromo-4-dimethylphosphoryl-benzene

  • CAS No. 4648-59-3

  • Cat. No. CS-0068255
  • Purity≥98%
  • MDL No.MFCD31718368

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-dimethylphosphoryl-benzene|CS-0068255

Structure of 4648-59-3

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General Information

  • CAS No. 4648-59-3
  • Cat. No. CS-0068255
  • Purity ≥98%
  • MDL No. MFCD31718368
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrOP
  • Molecular Weight 233.04
  • Synonym(s) None
  • SMILES BrC1=CC=C(P(C)(C)=O)C=C1

Description

(4-Bromophenyl)dimethylphosphine oxide features a brominated aryl group coupled to a phosphine oxide moiety, delivering enhanced electronic and steric properties. This bench-stable compound integrates readily into cross-coupling protocols and serves as a tailored ligand scaffold for transition metal catalysis.

Application

(4-Bromophenyl)dimethylphosphine oxide serves as a stable, bench-ready phosphine derivative enabling palladium-catalyzed cross-coupling reactions. Its bromo substituent facilitates further functionalization via Negishi, Suzuki-Miyaura, or Stille coupling protocols. The dimethylphosphine oxide group provides excellent functional group tolerance and ease of purification, making it a practical building block for the synthesis of biaryl scaffolds and complex pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.6971
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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