(6-Methoxy-2-methylpyridin-3-yl)boronic acid

Name: (6-Methoxy-2-methylpyridin-3-yl)boronic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 459856-12-3
Cat. No. CS-0084055
Purity≥95%
MDL No.MFCD05662386

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(6-Methoxy-2-methylpyridin-3-yl)boronic acid|CS-0084055

Structure of 459856-12-3

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General Information

CAS No. 459856-12-3
Cat. No. CS-0084055
Purity ≥95%
MDL No. MFCD05662386
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀BNO₃
Molecular Weight 166.97
Synonym(s) 2-Methyl-6-methoxypyridine-3-boronic acid
SMILES OB(C1=CC=C(OC)N=C1C)O

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions, delivering functionalized heteroaryl products with high efficiency. The methoxy and methyl substituents enhance solubility and stability under standard conditions, enabling straightforward handling in synthetic workflows.

Application

(6-Methoxy-2-methylpyridin-3-yl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The methoxy and methyl groups provide orthogonal functional handles for further derivatization, while the boronic acid moiety exhibits excellent bench stability and compatibility with diverse reaction conditions. Its predictable reactivity and ease of purification make it a practical choice for medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  126717-59-7
- ~%
- In-stock
  
  459856-12-3
References
- Eisai RandD Management Co., Ltd. Patent: EP1847535 A1, 2007 ; Location in patent: Page/Page column 123-124 ; EP 1847535 A1
Route2
- 5419-55-6
- In-stock
  
  126717-59-7
- ~%
- In-stock
  
  459856-12-3
References
- Gilligan, Paul J. Patent: US2003/125330 A1, 2003 ; US 20030125330 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 62.58
LogP -0.92158
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(6-Methoxy-2-methylpyridin-3-yl)boronic acid

CAS No. 459856-12-3

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