7-Fluoro-3,4-dihydroquinolin-2(1H)-one

Name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4590-52-7
Cat. No. CS-0043835
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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7-Fluoro-3,4-dihydroquinolin-2(1H)-one|CS-0043835

Structure of 4590-52-7

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Description

7-Fluoro-3,4-dihydroquinolin-2(1H)-one features a fluorinated quinolinone core with enhanced electron-withdrawing character due to the para-fluorine substitution. This scaffold integrates readily into medicinal chemistry libraries, offering improved metabolic stability and membrane permeability. The saturated ring system provides conformational rigidity beneficial for target binding.

Application

7-Fluoro-3,4-dihydroquinolin-2(1H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to bioactive molecules through established functionalization at the 2-position and C3–C4 ring system. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the lactam functionality supports diverse transformations including nucleophilic substitution and transition-metal-catalyzed coupling. Bench-stable and amenable to purification via standard chromatography, it functions as a reliable building block for targeted synthesis of pharmaceutical intermediates and CNS-active compounds.

General Information

CAS No. 4590-52-7
Cat. No. CS-0043835
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₈FNO
Molecular Weight 165.16
Synonym(s) None
SMILES O=C1NC2=C(C=CC(F)=C2)CC1

Computational Chemistry Data

TPSA 29.1
LogP 1.7104
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Tetrahydroquinoline compounds

Key Words

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7-Fluoro-3,4-dihydroquinolin-2(1H)-one

CAS No. 4590-52-7

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