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Structure of 457097-93-7
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Methyl 4-amino-3-(trifluoromethoxy)benzoate features a trifluoromethoxy group that enhances metabolic stability and lipophilicity, while the para-amino substituent enables direct coupling in peptide and pharmaceutical synthesis. This electron-rich aromatic scaffold integrates readily into bioactive scaffolds under standard conditions.
Methyl 4-amino-3-(trifluoromethoxy)benzoate serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethoxy group enhances metabolic stability and membrane permeability, while the amino and ester functionalities offer orthogonal reactivity for coupling, acylation, and cyclization reactions. The compound exhibits good bench stability and is amenable to standard purification methods, facilitating efficient integration into multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: