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CS-W001157 4
Total: USD 88.00

1-(4-Fluorophenyl)propan-1-one

  • CAS No. 456-03-1

  • Cat. No. CS-0059258
  • Purity≥95%
  • MDL No.MFCD00000356

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluorophenyl)propan-1-one|CS-0059258

Structure of 456-03-1

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General Information

  • CAS No. 456-03-1
  • Cat. No. CS-0059258
  • Purity ≥95%
  • MDL No. MFCD00000356
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO
  • Molecular Weight 152.17
  • Synonym(s) Ethyl 4-Fluorophenyl Ketone
  • SMILES CCC(C1=CC=C(F)C=C1)=O

Application

1-(4-Fluorophenyl)propan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the ketone functionality facilitates nucleophilic additions, condensations, and reductive amination reactions. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows for API intermediates and functionalized arenes.

Synthesis

  • Route1
    • 1-(4-Fluorophenyl)prop-2-en-1-ol|CS-0267097
      5724-03-8
    • ~95%
    • In-stock
      1-(4-Fluorophenyl)propan-1-one|CS-0059258
      456-03-1

    References

    • Bouziane, Asmae; Carboni, Bertrand; Bruneau, Christian; Carreaux, Francois; Renaud, Jean-Luc Tetrahedron, 2008 , vol. 64, # 51 p. 11745 - 11750
  • Route2
    • In-stock
      4'-Fluoroacetophenone|CS-W020117
      403-42-9
    • null|null
      68-12-2
    • ~65%
    • In-stock
      1-(4-Fluorophenyl)propan-1-one|CS-0059258
      456-03-1

    References

    • Li, Yang; Xue, Dong; Lu, Wei; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Organic Letters, 2014 , vol. 16, # 1 p. 66 - 69
  • Route3
    • In-stock
      N-Methoxy-N-methylpropanamide|CS-0122993
      104863-65-2
    • null|null
      460-00-4
    • ~15%
    • In-stock
      1-(4-Fluorophenyl)propan-1-one|CS-0059258
      456-03-1

    References

    • Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545 Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4184
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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