5-Bromobenzo[d]isoxazol-3-ylamine

Name: 5-Bromobenzo[d]isoxazol-3-ylamine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 455280-00-9
Cat. No. CS-W019384
Purity≥95%
MDL No.MFCD09834823

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromobenzo[d]isoxazol-3-ylamine|CS-W019384

Structure of 455280-00-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 455280-00-9
Cat. No. CS-W019384
Purity ≥95%
MDL No. MFCD09834823
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrN₂O
Molecular Weight 213.03
Synonym(s) 5-broMo-1,2-benzoxazol-3-aMine
SMILES BrC1=CC2=C(C=C1)ON=C2N

Description

5-Bromobenzo[d]isoxazol-3-ylamine features a brominated isoxazole ring fused to a benzene core, delivering a robust scaffold for bioactive compound synthesis. The amine group enables direct coupling in cross-coupling reactions and facilitates conjugation with polymers or drug candidates. This bench-stable heterocycle combines high reactivity with excellent handling properties under standard conditions.

Application

5-Bromobenzo[d]isoxazol-3-ylamine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient palladium-catalyzed cross-coupling reactions. Its brominated isoxazole core offers high functional group tolerance and bench stability, facilitating direct incorporation into pharmaceutical scaffolds via Suzuki-Miyaura and Buchwald-Hartwig protocols. The amine functionality further supports derivatization through acylation, alkylation, or cyclization reactions, making it a practical reagent for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Synthesis

Route1
- In-stock
  
  546-88-3
- 179897-89-3
- ~61%
- In-stock
  
  455280-00-9
References
- WO2010/138488 A1, ; Page/Page column 57-58 ; WO 2010/138488 A1
Route2
- 179897-89-3
- ~42%
- In-stock
  
  455280-00-9
References
- WO2006/122799 A1, ; Page/Page column 60-61 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 52.05
LogP 2.1725
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Benzoisoxazole compounds

Key Words

5-Bromobenzo[d]isoxazol-3-ylamine sigma5-Bromobenzo[d]isoxazol-3-ylamine manufacturer5-Bromobenzo[d]isoxazol-3-ylamine price5-Bromobenzo[d]isoxazol-3-ylamine structure5-Bromobenzo[d]isoxazol-3-ylamine SDSbuy 5-Bromobenzo[d]isoxazol-3-ylamine5-Bromobenzo[d]isoxazol-3-ylamine supplier5-Bromobenzo[d]isoxazol-3-ylamine uses5-Bromobenzo[d]isoxazol-3-ylamine molecular weightprice of 5-Bromobenzo[d]isoxazol-3-ylamine5-Bromobenzo[d]isoxazol-3-ylamine chemical name formula of 5-Bromobenzo[d]isoxazol-3-ylamine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

5-Bromobenzo[d]isoxazol-3-ylamine

CAS No. 455280-00-9

Recommended Products