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CS-W001157 4
Total: USD 88.00

1-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine

  • CAS No. 454482-11-2

  • Cat. No. CS-W008881
  • Purity≥97%
  • MDL No.MFCD11506069

*For research and further manufacturing use only, not for direct human use.

1-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine|CS-W008881

Structure of 454482-11-2

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General Information

  • CAS No. 454482-11-2
  • Cat. No. CS-W008881
  • Purity ≥97%
  • MDL No. MFCD11506069
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₂BNO₂
  • Molecular Weight 223.12
  • Synonym(s) 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1,2,3,6-tetrahydropyridine
  • SMILES CC1(C)OB(C(CC2)=CCN2C)OC(C)1C

Application

1-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate group enables efficient coupling under mild conditions, while the tetrahydropyridine core provides a stable, electron-rich heterocyclic scaffold. Its bench-stable nature and compatibility with diverse functional groups facilitate reliable synthesis of complex nitrogen-containing architectures in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • In-stock
      Bis(pinacolato)diborane|CS-D1216
      73183-34-3
    • 1-Methyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate|CS-0052479
      180692-27-7
    • ~%
    • In-stock
      1-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine|CS-W008881
      454482-11-2

    References

    • US2006/199817 A1, ; Page/Page column 37 ; US 20060199817 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.7
  • LogP   1.8797
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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