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CS-W001157 4
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Tert-butyl ((1R,2R)-2-hydroxycyclopentyl)carbamate

  • CAS No. 454170-16-2

  • Cat. No. CS-0166815
  • Purity≥97%
  • MDL No.MFCD11656037
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tert-butyl ((1R,2R)-2-hydroxycyclopentyl)carbamate|CS-0166815

Structure of 454170-16-2

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Description

Tert-butyl ((1R,2R)-2-hydroxycyclopentyl)carbamate features a chiral cyclopentane scaffold with a hydroxyl group at the 2-position and a tert-butoxycarbonyl-protected amine. This configuration enables stereocontrolled synthesis in complex natural product workflows, offering robust stability under standard conditions while allowing selective deprotection to reveal the primary amine functionality.

Application

Tert-butyl ((1R,2R)-2-hydroxycyclopentyl)carbamate serves as a versatile chiral building block for the synthesis of cyclopentane-containing scaffolds. The (1R,2R)-diol motif provides defined stereochemistry for asymmetric synthesis, while the tert-butyl carbamate group offers stable protection with facile removal under mild acidic conditions. Its bench-stable nature and compatibility with standard coupling reactions enable efficient access to complex cyclic architectures in medicinal chemistry and natural product synthesis.

General Information

  • CAS No. 454170-16-2
  • Cat. No. CS-0166815
  • Purity ≥97%
  • MDL No. MFCD11656037
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₃
  • Molecular Weight 201.26
  • Synonym(s) Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
  • SMILES O=C(OC(C)(C)C)N[C@H]1[C@H](O)CCC1

Computational Chemistry Data

  • TPSA   58.56
  • LogP   1.4245
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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