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CS-W001157 4
Total: USD 88.00

5-Bromo-2,4-difluoroaniline

  • CAS No. 452-92-6

  • Cat. No. CS-W015244
  • Purity≥98%
  • MDL No.MFCD03426368

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,4-difluoroaniline|CS-W015244

Structure of 452-92-6

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General Information

  • CAS No. 452-92-6
  • Cat. No. CS-W015244
  • Purity ≥98%
  • MDL No. MFCD03426368
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂N
  • Molecular Weight 208.00
  • Synonym(s) Benzenamine, 5-bromo-2,4-difluoro-; 5-Bromo-2,4-difluoroaniline
  • SMILES NC1=CC(Br)=C(F)C=C1F

Description

5-Bromo-2,4-difluoroaniline features a strategically positioned bromine atom and two fluorine substituents on the aromatic ring, enabling precise functionalization in pharmaceutical intermediates. The electron-deficient aryl framework facilitates coupling reactions under standard conditions, while its bench-stable nature supports reliable handling in synthetic workflows.

Synthesis

  • Route1

    References

    • Jiang, Yu; Chen, Chien-An; Lu, Kai; Daniewska, Irena; De Leon, John; Kong, Ron; Forray, Carlos; Li, Boshan; Hegde, Laxminarayan G.; Wolinsky, Toni D.; Craig, Douglas A.; Wetzel, John M.; Andersen, Kim; Marzabadi, Mohammad R. Journal of Medicinal Chemistry, 2007 , vol. 50, # 16 p. 3870 - 3882
  • Route2

    References

    • Finger; Oesterling Journal of the American Chemical Society, 1956 , vol. 78, p. 2593,2596

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.3095
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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