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CS-W001157 4
Total: USD 88.00

1-Cyclohexyl-4-methylbenzene

  • CAS No. 4501-36-4

  • Cat. No. CS-W020170
  • Purity≥98%
  • MDL No.MFCD09032429

*For research and further manufacturing use only, not for direct human use.

1-Cyclohexyl-4-methylbenzene|CS-W020170

Structure of 4501-36-4

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General Information

  • CAS No. 4501-36-4
  • Cat. No. CS-W020170
  • Purity ≥98%
  • MDL No. MFCD09032429
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈
  • Molecular Weight 174.28
  • Synonym(s) 4-Methyl-1-cyclohexylbenzene
  • SMILES CC1=CC=C(C2CCCCC2)C=C1

Description

1-Cyclohexyl-4-methylbenzene features a rigid aromatic core paired with a bulky cyclohexyl substituent, conferring enhanced thermal stability and reduced reactivity. The para-methyl group introduces mild electron-donating character, while the aliphatic cyclohexyl moiety imparts hydrophobicity and steric shielding. This combination enables utility as a non-polar solvent component or structural motif in advanced polymer synthesis under standard conditions.

Application

1-Cyclohexyl-4-methylbenzene serves as a stable, bench-ready aromatic building block featuring orthogonal functional handles for downstream modification. The cyclohexyl group provides lipophilic character and conformational rigidity, while the para-methyl substituent enables selective oxidation or C–H functionalization. This compound facilitates the synthesis of complex alkylated arenes and serves as a structural motif in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      542-18-7
    • null|null
      4294-57-9
    • ~46%
    • In-stock
      4,4'-Dimethyldiphenyl|CS-W017094
      613-33-2
    • In-stock
      1-Cyclohexyl-4-methylbenzene|CS-W020170
      4501-36-4

    References

    • Qian, Xin; Dawe, Louise N.; Kozak, Christopher M. Dalton Transactions, 2011 , vol. 40, # 4 p. 933 - 943
  • Route2
    • In-stock
      Bromocyclohexane|CS-W017925
      108-85-0
    • null|null
      4294-57-9
    • ~77%
    • In-stock
      1-Cyclohexyl-4-methylbenzene|CS-W020170
      4501-36-4
    • null|null
      110-82-7
    • null|null
      110-83-8

    References

    • Xia, Chong-Liang; Xie, Cun-Fei; Wu, Yu-Feng; Sun, Hong-Mei; Shen, Qi; Zhang, Yong Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8135 - 8144
  • Route3
    • null|null
      542-18-7
    • null|null
      4294-57-9
    • ~53%
    • In-stock
      1-Cyclohexyl-4-methylbenzene|CS-W020170
      4501-36-4
    • null|null
      110-82-7
    • null|null
      110-83-8

    References

    • Xia, Chong-Liang; Xie, Cun-Fei; Wu, Yu-Feng; Sun, Hong-Mei; Shen, Qi; Zhang, Yong Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8135 - 8144

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3082
Class : 9
Packing Group : Ⅲ
Hazard Statements : H304-H315-H319-H410
Precautionary Statements : P264-P273-P280-P302+P352-P331-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.04272
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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