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Structure of 450-90-8
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4-Fluoro-1-iodo-2-methoxybenzene features a strategically positioned iodine atom flanked by electron-withdrawing fluorine and electron-donating methoxy groups, enabling efficient palladium-catalyzed cross-coupling reactions under standard conditions. This aryl iodide exhibits enhanced reactivity and stability for use in synthesizing complex pharmaceutical intermediates and functionalized aromatic scaffolds.
4-Fluoro-1-iodo-2-methoxybenzene serves as a versatile aryl halide building block in palladium-catalyzed cross-coupling reactions. The ortho-fluoro and methoxy substituents enable directed functionalization and enhance regioselectivity in Suzuki-Miyaura and Negishi couplings. Its bench-stable, crystalline form facilitates handling and purification, making it well-suited for iterative synthesis of complex aromatic scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: