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Structure of 450-62-4
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7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline features a trifluoromethyl group at the 7-position of a saturated quinoline core, imparting enhanced electron-withdrawing character and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, offering improved membrane permeability and resistance to oxidative degradation in bioactive molecule design.
7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline serves as a valuable heterocyclic building block in medicinal chemistry, offering enhanced metabolic stability and lipophilicity due to the trifluoromethyl group. It functions as a key scaffold for bioactive molecule synthesis, demonstrating compatibility with standard functionalization protocols including electrophilic substitution and palladium-catalyzed coupling reactions. Its bench-stable nature and predictable reactivity facilitate efficient downstream derivatization in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: