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CS-W001157 4
Total: USD 88.00

(5-Methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid

  • CAS No. 446299-81-6

  • Cat. No. CS-0203502
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid|CS-0203502

Structure of 446299-81-6

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General Information

  • CAS No. 446299-81-6
  • Cat. No. CS-0203502
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₅BN₂O₃
  • Molecular Weight 270.09
  • Synonym(s) Ozenoxacin Impurity 7
  • SMILES O=C(N(C)C1=NC=C(B(O)O)C=C1C)C2=CC=CC=C2

Description

This boronate moiety integrates a methyl-substituted pyridine core with an N-methylbenzamide tether, delivering enhanced stability and solubility in polar solvents. The electron-deficient boronic acid group facilitates efficient Suzuki-Miyaura coupling under standard conditions, enabling rapid construction of complex aryl architectures.

Application

(5-Methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The pyridine core provides enhanced solubility and stability, while the N-methylbenzamide group offers favorable electronic modulation and orthogonal functional group tolerance. Its bench-stable nature and compatibility with diverse reaction partners make it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   73.66
  • LogP   0.34642
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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