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CS-W001157 4
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2-Fluorobenzohydrazide

  • CAS No. 446-24-2

  • Cat. No. CS-0040498
  • Purity≥96%
  • MDL No.MFCD00025112

*For research and further manufacturing use only, not for direct human use.

2-Fluorobenzohydrazide|CS-0040498

Structure of 446-24-2

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General Information

  • CAS No. 446-24-2
  • Cat. No. CS-0040498
  • Purity ≥96%
  • MDL No. MFCD00025112
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FN₂O
  • Molecular Weight 154.14
  • Synonym(s) 2-Fluorobenzoylhydrazine
  • SMILES O=C(NN)C1=CC=CC=C1F

Description

2-Fluorobenzohydrazide features a fluorinated aromatic ring paired with a hydrazide functional group, enabling direct incorporation into heterocyclic scaffolds. This bench-stable reagent facilitates efficient access to bioactive compounds through coupling reactions and cyclization processes under standard conditions.

Synthesis

  • Route1

    References

    • CONCERT PHARMACEUTICALS, INC.; HARBESON, Scott, L.; TUNG, Roger, D.; LIU, Julie, F. Patent: WO2011/5520 A1, 2011 ; Location in patent: Page/Page column 31 ; WO 2011/005520 A1
  • Route2

    References

    • Li, Yan; Liu, Jie; Zhang, Hongquan; Yang, Xiangping; Liu, Zhaojie Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2278 - 2282
  • Route3

    References

    • Khan, Mahmood-Ul-Hassan; Hameed, Shahid; Yasin, Khawaja A.; Akhtar, Tashfeen; Khan, Khalid M. Monatshefte fur Chemie, 2010 , vol. 141, # 4 p. 479 - 484

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.4292
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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