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CS-W001157 4
Total: USD 88.00

1-Fluoro-4-methyl-2-nitrobenzene

  • CAS No. 446-11-7

  • Cat. No. CS-W002019
  • Purity≥98%
  • MDL No.MFCD00007060
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Fluoro-4-methyl-2-nitrobenzene|CS-W002019

Structure of 446-11-7

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Description

1-Fluoro-4-methyl-2-nitrobenzene features a fluorine atom at the ortho position relative to a nitro group, creating a highly electron-deficient aromatic system. This combination enables direct electrophilic substitution and facilitates transition metal-catalyzed coupling reactions. The methyl substituent enhances solubility and provides a handle for further functionalization. The molecule exhibits excellent bench stability and compatibility with standard synthetic protocols in medicinal chemistry and materials science applications.

Application

1-Fluoro-4-methyl-2-nitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its activated aryl fluoride functionality. The ortho-nitro group enhances electrophilicity, facilitating nucleophilic substitution under mild conditions. Its bench-stable nature and compatibility with diverse functional groups support efficient route development for complex heterocyclic scaffolds and API intermediates.

General Information

  • CAS No. 446-11-7
  • Cat. No. CS-W002019
  • Purity ≥98%
  • MDL No. MFCD00007060
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) 4-Fluoro-3-nitrotoluene
  • SMILES Cc1ccc(c(c1)[N+](=O)[O-])F

Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.04232
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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