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Structure of 446-10-6
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4-Fluoro-1-methyl-2-nitrobenzene features a strategically positioned nitro group flanked by fluorine and methyl substituents, enabling precise electronic tuning for cross-coupling reactions. This electron-deficient aryl building block integrates efficiently into complex molecular architectures under standard conditions.
4-Fluoro-1-methyl-2-nitrobenzene serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive aryl fluoride and electron-withdrawing nitro group. The methyl substituent enhances metabolic stability, while the ortho-nitro group facilitates subsequent reductions and cyclizations. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for constructing complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: