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CS-W001157 4
Total: USD 88.00

2-Fluorobenzamide

  • CAS No. 445-28-3

  • Cat. No. CS-0149974
  • Purity≥98%
  • MDL No.MFCD00007970

*For research and further manufacturing use only, not for direct human use.

2-Fluorobenzamide|CS-0149974

Structure of 445-28-3

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General Information

  • CAS No. 445-28-3
  • Cat. No. CS-0149974
  • Purity ≥98%
  • MDL No. MFCD00007970
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) o-Fluorobenzoic acid amide
  • SMILES NC(C1=CC=CC=C1F)=O

Description

2-Fluorobenzamide delivers a fluorinated aromatic scaffold with enhanced metabolic stability and improved membrane permeability. The ortho-fluoro substitution modulates electronic properties, enabling precise tuning of reactivity in pharmaceutical intermediates. This bench-stable amide integrates seamlessly into complex synthesis pathways, offering reliable functionality under standard conditions.

Application

2-Fluorobenzamide serves as a versatile building block in medicinal chemistry, offering a fluorinated aromatic scaffold with predictable reactivity. The amide group enables direct functionalization or coupling reactions, while the ortho-fluoro substituent provides enhanced metabolic stability and modulates electronic properties. Its bench-stable nature facilitates straightforward handling and purification, making it well-suited for use in standard amide bond formations, Suzuki couplings, and heterocycle synthesis.

Synthesis

  • Route1
    • null|null
      394-47-8
    • ~97%
    • In-stock
      2-Fluorobenzamide|CS-0149974
      445-28-3

    References

    • Kim, Eun Sun; Lee, Hyun Seung; Kim, Sung Hwan; Kim, Jae Nyoung Tetrahedron Letters, 2010 , vol. 51, # 12 p. 1589 - 1591
  • Route2

    References

    • Song, Qiuling; Feng, Qiang; Yang, Kai Organic Letters, 2014 , vol. 16, # 2 p. 624 - 627
  • Route3
    • (E)-N-[(2-fluorophenyl)methylidene]hydroxylamine|CS-W020474
      24652-66-2
    • ~84%
    • In-stock
      2-Fluorobenzamide|CS-0149974
      445-28-3

    References

    • Garcia-Alvarez, Rocio; Diaz-Alvarez, Alba E.; Borge, Javier; Crochet, Pascale; Cadierno, Victorio Organometallics, 2012 , vol. 31, # 17 p. 6482 - 6490

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   0.9246
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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