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CS-W001157 4
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cis-Piperidine-3,4-diol hydrochloride

  • CAS No. 443648-89-3

  • Cat. No. CS-0049724
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

cis-Piperidine-3,4-diol hydrochloride|CS-0049724

Structure of 443648-89-3

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General Information

  • CAS No. 443648-89-3
  • Cat. No. CS-0049724
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO₂
  • Molecular Weight 153.61
  • Synonym(s) (3R,4S)-rel-3,4-Piperidinediol Hydrochloride
  • SMILES Cl.O[C@@H]1CCNC[C@@H]1O

Description

cis-Piperidine-3,4-diol hydrochloride features a rigid, cis-configured diol framework that enhances its conformational stability and solubility in polar solvents. This bench-stable derivative integrates readily into complex synthetic sequences, serving as a key chiral building block for bioactive molecule construction.

Application

cis-Piperidine-3,4-diol hydrochloride serves as a stereochemically defined scaffold for the synthesis of bioactive heterocycles and natural product analogs. Its constrained cis-diol geometry enables predictable regioselective functionalization, while the hydrochloride salt enhances solubility and stability under standard laboratory conditions. The molecule functions as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds, offering excellent compatibility with common coupling and derivatization protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.49
  • LogP   -0.8767
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   0

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