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CS-W001157 4
Total: USD 88.00

5-Methylpyridine-2-carboxylic acid

  • CAS No. 4434-13-3

  • Cat. No. CS-D1603
  • Purity≥98%
  • MDL No.MFCD01704358

*For research and further manufacturing use only, not for direct human use.

5-Methylpyridine-2-carboxylic acid|CS-D1603

Structure of 4434-13-3

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General Information

  • CAS No. 4434-13-3
  • Cat. No. CS-D1603
  • Purity ≥98%
  • MDL No. MFCD01704358
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) 5-Methyl-2-pyridinecarboxylic acid; 2-Carboxy-5-methylpyridine; 5-Methylpicolinic acid; 5-methyl-picolinicaci
  • SMILES O=C(C1=NC=C(C)C=C1)O

Description

5-Methylpyridine-2-carboxylic acid features a pyridine core with strategically positioned methyl and carboxylic acid groups, enabling integration into bioactive scaffolds. The electron-deficient heterocycle pairs with the polar carboxylate for enhanced solubility and metal coordination. This robust, bench-stable derivative supports modular synthesis in medicinal chemistry and materials science applications.

Application

5-Methylpyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry and catalysis, offering a well-defined pyridine scaffold with orthogonal functional handles. The carboxylic acid group enables direct amidation, esterification, or coupling reactions, while the methyl substituent provides a site for selective oxidation or further functionalization. Its stability under standard reaction conditions and compatibility with diverse synthetic transformations make it a practical choice for constructing heterocyclic frameworks and API intermediates.

Synthesis

  • Route1
    • null|null
      589-93-5
    • ~19%
    • In-stock
      5-Methylpyridine-2-carboxylic acid|CS-D1603
      4434-13-3
    • In-stock
      6-Methylnicotinic acid|CS-W008333
      3222-47-7
    • 2,5-Pyridinedicarboxylic acid Nicotinic Acid  Impurity|CS-0229402
      100-26-5

    References

    • Pharmaceutical Chemistry Journal, , vol. 26, # 11/12 p. 894 - 896 Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 11-12 p. 81 - 83
  • Route2
    • null|null
      589-93-5
    • ~%
    • In-stock
      5-Methylpyridine-2-carboxylic acid|CS-D1603
      4434-13-3

    References

    • Justus Liebigs Annalen der Chemie, , vol. 613, p. 153,155, 162
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 78, p. 1932,1934

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P280-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.08822
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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