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CS-W001157 4
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(R)-4,4'-Bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-3,3'-bipyridine

  • CAS No. 442905-33-1

  • Cat. No. CS-W011398
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-4,4'-Bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-3,3'-bipyridine|CS-W011398

Structure of 442905-33-1

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General Information

  • CAS No. 442905-33-1
  • Cat. No. CS-W011398
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₆H₅₀N₂O₄P₂
  • Molecular Weight 756.85
  • Synonym(s) Xyl-p-phos, (R)-
  • SMILES [P(xylyl)2]C1=C(C2=C(OC)N=C(OC)C=C2[P(xylyl)2])C(OC)=NC(OC)=C1

Description

Alloc-Val-Ala-OH is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   62.7
  • LogP   2.79484
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   5

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