cis-4-Hydroxy-L-proline hydrochloride

Name: cis-4-Hydroxy-L-proline hydrochloride
Brand: ChemScene
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CAS No. 441067-49-8
Cat. No. CS-0028245
Purity≥97%
MDL No.MFCD09953187

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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cis-4-Hydroxy-L-proline hydrochloride|CS-0028245

Structure of 441067-49-8

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General Information

CAS No. 441067-49-8
Cat. No. CS-0028245
Purity ≥97%
MDL No. MFCD09953187
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₀ClNO₃
Molecular Weight 167.59
Synonym(s) None
SMILES [H]Cl.O=C(O)[C@H]1NC[C@@H](O)C1

Description

cis-4-Hydroxy-L-proline (hydrochloride) delivers a stabilized, moisture-tolerant form of the bioactive proline derivative, featuring a cis-configured hydroxyl group critical for collagen mimicry. This bench-stable variant simplifies handling in peptide synthesis and structural studies, enabling reliable incorporation into polypeptide scaffolds where precise stereochemistry governs conformational integrity.

Application

cis-4-Hydroxy-L-proline (hydrochloride) serves as a key building block in the synthesis of bioactive peptides and natural product analogs, offering enhanced conformational rigidity due to its cis-configured hydroxyl group. The hydrochloride salt improves solubility and handling stability, facilitating straightforward incorporation into solid-phase peptide synthesis workflows. Its well-documented role in stabilizing type I collagen-like structures makes it valuable for medicinal chemistry projects targeting extracellular matrix-related therapeutics.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 69.56
LogP -0.7844
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Life Science ADC Related Compound Non-cleavable linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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cis-4-Hydroxy-L-proline hydrochloride

CAS No. 441067-49-8

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