H-Thr(tBu)-OH

Name: H-Thr(tBu)-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4378-13-6
Cat. No. CS-W017447
Purity≥97%
MDL No.MFCD00037766

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 4378-13-6

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General Information

CAS No. 4378-13-6
Cat. No. CS-W017447
Purity ≥97%
MDL No. MFCD00037766
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₇NO₃
Molecular Weight None
Synonym(s) None
SMILES C[C@H]([C@@H](C(O)=O)N)OC(C)(C)C

Description

H-Thr(tBu)-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a tert-butyl-protected hydroxyl group. This protected threonine variant enables efficient incorporation into peptide sequences under standard coupling conditions, offering enhanced solubility and reduced side-reaction risks during solid-phase synthesis.

Application

H-Thr(tBu)-OH serves as a robust, bench-stable building block for peptide synthesis, enabling efficient incorporation of β-hydroxyalanine units. The tert-butyl group provides excellent protection of the hydroxyl functionality, ensuring compatibility with standard coupling protocols and orthogonal deprotection under mild acidic conditions. Its defined stereochemistry and high purity support reliable access to complex peptide architectures and glycopeptide analogs.

Synthesis

Route1
- In-stock
  
  71989-35-0
- ~97%
- In-stock
  
  4378-13-6
References
- Chen, Chun-Chi; Rajagopal, Basker; Liu, Xuan Yu; Chen, Kuan Lin; Tyan, Yu-Chang; Lin, Fui; Lin, Po-Chiao Amino Acids, 2014 , vol. 46, # 2 p. 367 - 374
Route2
- In-stock
  
  71989-35-0
- ~85%
- 4425-82-5
- In-stock
  
  4378-13-6
References
- Hoeck, Stefan; Marti, Roger; Riedl, Rainer; Simeunovic, Marina Chimia, 2010 , vol. 64, # 3 p. 200 - 202
Route3
- In-stock
  
  16966-09-9
- ~%
- In-stock
  
  4378-13-6
References
- Nakajima, Kiichiro; Neya, Masahiro; Yamada, Shinichi; Okawa, Kenji Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 9 p. 3049 - 3050

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 72.55
LogP 0.6019
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Other Classifications

Bioactive Molecules Peptides

Catalysts and Ligands Organocatalytic Small Molecules Other Catalytic Small Molecules

Life Science Amino Acids and their Derivatives Threonine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids Side Chain Protected Amino Acids (N,C-termini Free)

Catalysis Asymmetric Synthesis Chiral Catalysts, Chiral Ligands, Chiral Reagents Chiral Organocatalysts (Other)

Catalysis Organocatalysts Asymmetric Organocatalysts

Catalysis Oxidation Oxidation Organocatalysts

Key Words

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H-Thr(tBu)-OH

CAS No. 4378-13-6

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