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CS-W001157 4
Total: USD 88.00

3-Fluoro-2-methoxyaniline

  • CAS No. 437-83-2

  • Cat. No. CS-W007841
  • Purity≥98%
  • MDL No.MFCD00007759

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-methoxyaniline|CS-W007841

Structure of 437-83-2

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General Information

  • CAS No. 437-83-2
  • Cat. No. CS-W007841
  • Purity ≥98%
  • MDL No. MFCD00007759
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight 141.14
  • Synonym(s) 3-fluoro-O-anisidine
  • SMILES FC1=CC=CC(=C1OC)N

Description

3-Fluoro-2-methoxyaniline features a fluorinated aromatic ring paired with a methoxy group, delivering enhanced electron density and metabolic stability. This ortho-substituted aniline integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under standard conditions. The compound exhibits robust bench stability and facilitates the synthesis of bioactive molecules requiring precise electronic tuning.

Application

3-Fluoro-2-methoxyaniline serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its ortho-substituted aryl amine functionality offers enhanced reactivity in electrophilic aromatic substitution and coupling reactions, while the methoxy and fluoro groups provide favorable electronic modulation and metabolic stability. The compound exhibits good bench stability and is compatible with standard synthetic workflows, facilitating efficient purification and integration into multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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