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CS-W001157 4
Total: USD 88.00

2,6-Difluorobenzaldehyde

  • CAS No. 437-81-0

  • Cat. No. CS-W007380
  • Purity≥96%
  • MDL No.MFCD00010293

*For research and further manufacturing use only, not for direct human use.

2,6-Difluorobenzaldehyde|CS-W007380

Structure of 437-81-0

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General Information

  • CAS No. 437-81-0
  • Cat. No. CS-W007380
  • Purity ≥96%
  • MDL No. MFCD00010293
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₂O
  • Molecular Weight 142.10
  • Synonym(s) 3,4,5-Triflurobenzenenitrile
  • SMILES FC(C=CC=C1F)=C1C=O

Description

2,6-Difluorobenzaldehyde can be used as a reactant to synthesize: 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil via one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea. 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole by reacting with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.(3E)-4-(2,6-Difluorophenyl)-3-buten-2-one by Wittig olefination reaction with acetylmethylidenetriphenyl phosphorane.Methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating with methyl thioglycolate in the presence of K2CO3.

Application

2,6-Difluorobenzaldehyde serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability and modulated electronic properties due to the ortho-fluorine substituents. Its aldehyde functionality enables facile incorporation into imines, oximes, and Wittig reactions, while the fluorinated aromatic ring exhibits excellent bench stability and compatibility with diverse reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314-H412
Precautionary Statements : P210-P260-P264-P273-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.7773
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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